food security – GMO SAFETY

Analysis

GMO Plants as an important strategy to adapting climate-smart changes

Editorial Posted On May 23, 2016

One of the greatest worries about increased temperatures is the corn impact it has on Agricultural practices. This is because heat waves are perceived to have an impact on the atmospheric humidity through the creation of a drought condition. In the long-term, this extends into reducing the amount of water that is in the soil, rivers, and lakes among corn water sources. Another under worry about the high temperatures is that relating to the prospects of food crops bidding their natural habitats a good bye. According to expert agronomists, if the temperatures rise beyond a certain threshold, there will be anticipated a decline of yield significantly.

However, climate change is not a good thing as people may want to describe it. This is because of the problems that come along with it apart from the high temperatures that exceed the tolerant limits of various species of crops. The alteration in the normal patterns of the weather has a great impact on the systems of agriculture in certain areas. Similarly, variability in the climatic patterns may lead to draft that gives rise to floods during seasons that would otherwise be dry under normal conditions. This causes dryness during wet seasons and thus affects the crops that have been planted. This leads to the crippling of crops for long periods of time.

One of the ways in which this can be taken care of is through adaptation of the genetically engineered crops species that are tolerant to harsh environmental conditions. This means that GMO plants can be produced so that they can withstand drought, floods, extreme temperatures as well as novel breeds of pests. This serves as a promising area that can help in salvaging the extreme changes in the climatic patterns that hit hard the agriculturally productive regions across the globe. This requires employing biotechnology techniques that will help in promoting the crop adaptation.

GM crops in stress conditions
The effects of the alteration in the weather have been attributed as one of the leading causes of changes in the soil conditions. This often leads to toxic salt levels in the ground that are not favorable for crops. In Australia, a gene has been identified in Wheat to play a central role in marker-assisted breeding has promised to offer great avenues of taking care of the salt concentrations in the soil. This is by conferring salt tolerance traits in the GM crops. Based on a report given by the FAO (2010), there is a possibility that the use of biotechnology based techniques can lead to the salt tolerant crops through genetic engineering. This is after a long period of 10 years of genetic research utilizing transgenic plants to alter the salt tolerance. The value and success of this particular approach are anticipated in the filed experiments that are on-going in Australia. The success of this approach is one of the greatest techniques of GMO drought tolerant crops and thus promoting the climate-smart farming technology.

GMO maize, MON87460 to feed people in droughts
There have been significant efforts put in place by the genetic engineers in converting crops so that they can efficiently use carbon dioxide and water. This means that significant conversion of the metabolism of the plants from carbon 3 to carbon four metabolisms has to occur. The carbon four plants that include maize, as well as sugarcane, have a more efficient way of using their water and carbon dioxide. This means that successful genetic engineering of drought tolerance genes has currently been found impossible because of the major changes that have to be made in the metabolic cycle.

In some parts of Africa, Australia, and Europe, there is evidence of plants growing in the absence of moisture after prolonged periods of droughts. Recently, there has been the release of maize that is tolerant to droughts by Monsanto. The maize is referred to as MON87460, and there is anticipation for the marketing consent release for this batch of corn. It is under conditions that have limited amounts of water that the grain yield for the corn loss was reduced significantly when compared to the conventional maize. However, just like the regular corn, MON87460 maize still suffers from loss of yield especially in conditions where the amount of water is limited. This often has been reported to happen during the stage of flowering and the grainfill period. This is because it is during this time that the yields of maize are greatly influenced by their sensitivity to stress conditions. Because of this, the kernel development is disrupted significantly.

Additionally, the maize grain yield of the MON87460 maize has the potential to reach zero level especially under conditions of severe water deficiency. The most important factor to note is that the information that is available from the Monsanto is not inclusive of the evidence that indeed the GMO maize MON87460 will thrive in conditions of limited water.

Currently, there are researches taking place in France on a wide range of crops that have the ability to withstand inhospitable climatic conditions. This includes research on Grapes that are designed to fight against common environmental viruses as well as the wheat in Australia striving to produce foods that have lower glycemic levels. Additionally, other studies are those focusing on cassavas that are resistant to ceratin viruses and bananas that contain high levels of iron. All these studies strive at ensuring that we have GM plants that are climate smart and can assure the future of food security.

Conclusion
A wide range of miracle GMO plants that are capable of thriving in marginal lands is the focus of most researches today. This is to ensure that there is the development of genetically engineered crops that are tolerant to abiotic stresses that include high salt concentrations, droughts among other factors. However, in as much as these promises are highly manipulative of the common farmers, the results of which are still at the level of mere speculations. If we have successful genetic engineering of pants that will confer drought resistance traits, then it will be a happy future for all the people across the globe. This is because it means sufficient food and thus food security. However, there is still the challenge of making significant alterations to the metabolism of the plant.

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Research / Scientific debate

The safety of genetically modified plants produced through use of biotechnology

Editorial Posted On May 6, 2016

The safety of genetically modified plants has been at the forefront of many scientific debates trying to ascertain the safety of the plants and its produce to human and animal health upon consumption. This is where the Society of Toxicology comes into play to ensure that they offer maximum protection and enhancement of the human, animal as well as environmental health. This is achieved through the sound application of biotechnological processes in production. Typically, in this context, biotechnology refers to the processes that involve the transfer of transgenes from organisms to plants hence food production. This may also apply to the expression of individual existing genes s modified permanently by employing genetic engineering techniques. Therefore, it is important for you to realize that it is not the method of modification of plants that is the concern of human and environmental safety but rather the product.

In this article, the question we will try to answer is whether the product of the transgene is capable of presenting a risk to both the consumers and the handlers of genetically modified plants. This means that the potential toxicity of the transgene plant product has to be considered by case-by-case design. This means that taking into consideration the possibility that the transgene produces toxins that are known such as protein allergens.

Toxin production

The level of toxins that are produced by the genetically modified plants and the threat it possesses to the producers and the consumers is often the focus of interest of toxicologist. This is through the use of standard toxicological approaches such as the evaluation of Bt (Bacillus thuringiensis) endotoxins as described by US EPA in 2001. The safety of these plants is therefore determined by their digestibility and absence of intrinsic activity in the mammalian systems. In this case, therefore, in-depth comprehension of the mechanism of action of the Bt toxin and the selective pressure that takes place in their biochemical systems increases the surety of safety assessments. However, each transgenic novel product of plants has to be considered individually. This is based on the levels of exposure, potency in causing toxic effects among other safety paradigms.

Allergen production

Allergenicity is one of the major safety concerns of consuming foods derived from transgenic plants. In as much as we are raising eyebrows on the safety of GM plants and their products, consumption of conventional foods is not equally safe. This is because the occurrence of allergies has been reported with conventional foods. However, some of the issues that have to be addressed with a high level of stringency are the potential Allergenicity associated with genetically modified plants/crops. Some of these issues include;

Do the products of the novel gene inserted into plants elicit allergic reactions in humans or animals that are already sensitized to the same protein? Does the transgenic approach employ induce alteration of the level of expression of the proteins that exist in the host crop? Do the products derived from genetically engineered plants used for food have the ability to induce de novo sensitization among humans or animals that are susceptible?

Characterization of the potentially allergenic proteins produced by the GM plants produced through biotechnological technique is based on three factors;

Structural similarity, serological and sequence homology; the principal aim of this is to determine whether and to what level does the protein produced by the genetically modified foods have similarity to other known proteins that have the potential of causing allergies among humans and animals. This is through the determination of the overall structure of the protein of interest and its similarity to allergens that are known. The use of the protein database offers the possibility of determining the similarity of the novel protein of interest with those of allergens that are known on their sequence alignments homology. This could also be compared to discrete motifs and domains in the protein where there is complete sequence similarity with that which is present in known allergens, therefore, indicating possibility of shared protein epitopes. The third approach is the use of serological techniques to determine whether there are specific IgE antibodies present in the serum of sensitized humans or animals capable of recognizing the protein of interest.

Proteolytic stability: According to research, there is evidence of a correlation between protein resistance to proteolytic digestion and their potential to cause allergic reactions. The theory, in this case, is that relative resistance plays a role in inducing allergic responses on condition that the protein of interest possesses allergenic characteristics. In this case, the approach that is effective is characterizing the susceptibility of the protein of interest to its digestibility by pepsins and other gastric stimulated proteins. However, it is important to note that this approach alone may not be sufficient for the identification of cross-reactive proteins that have the potential of eliciting allergic responses in foods.

Use of animal models: animal models are the other biotechnological approach that may be used to assess the safety of products derived from GM plants. Currently, there is the absence of adequate animals that can be used as model organisms to simulate the same environment as humans thus facilitating their use in identification of protein allergens. However, there is ongoing research geared towards the development of techniques that are suitable for characterization of allergic responses in rodents and other species that mimic human physiological surrounding.

The safety of the GM plant and plant products has been lots of concern across the globe. However, it is important to appreciate the fact that despite the safety concerns, it is also playing a significant role in charting the path towards food security. However, a major limitation is predicted to occur in future if the transgenic technology gives rise to more substantial and complexity in the products derived from GM plants. This means that there is a need for improving the methods that are used in plant profiling of their proteins as well as studying their gene expression. This is especially important in detecting any changes that occur unexpectedly in the GM plants to determine their substantial equivalence. Therefore, continuity in the evolution of toxicological methods, as well as regulatory strategies, are necessary to be put in place to ensure that safety of GM plants and products comes first as far as human, animal and environmental factors are concerned.

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